Dehydroepiandrosterone, or DHEA, is a naturally occurring hormone produced in the adrenal glands and the reproductive organs of both men and women. DHEA is one of the most abundant hormones in humans. Its levels peak in early adulthood and gradually decline with age. DHEA plays an important role in the synthesis of estrogen and testosterone, two key hormones that influence one’s reproductive health and fertility.
DHEA has attracted growing interest in the fertility field for its potential to improve egg quality and support ovarian function—which improves fertility. Multiple studies have shown that supplementing with DHEA may help women, especially those over 40 or those with diminished ovarian reserve, improve their chances of a successful pregnancy. DHEA supplementation has been linked to reduce the risk of miscarriages, increase the quantity of eggs produced, and improve embryo quality.
Who Should Consider Taking DHEA?
DHEA supplementation is often recommended for women who:
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Are over 40 years old
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Have a diminished ovarian reserve (fewer eggs or lower ovarian function)
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Have had a poor response in previous IVF cycles
It’s important to note that DHEA works best for women with low androgen levels. DHEA is readily available over the counter in the United States. However, taking it without a hormonal need may not provide the benefits shown. DHEA is not recommended for women who are at risk or have a family history of hormonal cancer. For women who have PCOS, or endometriosis, it is recommended to consult a doctor about using DHEA. Inappropriate use of DHEA could disrupt your body’s natural hormonal balance and have unwanted side effects.
Side Effects of DHEA
The recommended daily dose for DHEA is 25-75 mg. When taken properly and at the right dosage, DHEA is generally safe and well-tolerated. Some mild and temporary side effects can include:
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Oily skin or acne
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Mild hair loss/thinning
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Mood changes
These side effects usually resolve after stopping supplementation. These doses for fertility support claim to carry minimal risks when overseen by a healthcare professional.
How to Choose a High-Quality DHEA Supplement
What most consumers may not realize is that not all DHEA supplements are created equal. It is important to recognize that quality and dosage can vary widely among brands, and many over-the-counter products don’t match the formulations proven effective in clinical studies. Additionally, research has shown that supplement labels may inaccurately list the dose or the active ingredients contained.
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Look for NSF or USP certifications. These labels verify that products are accurately labeled and contaminant free.
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Look for micronized DHEA, which is designed to enhance solubility and absorption in the body due to its small particle size
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Use supplements recommended or prescribed by your fertility specialist or clinic
Choosing the right product ensures you get the proper benefits needed to support your fertility journey.
Talk to Your Doctor: Personalized Fertility Support
Before starting DHEA or any supplement, it’s important to consult with a reproductive endocrinologist or fertility expert. They can assess your hormone levels through a simple blood test and examine your medical history to determine if DHEA is right for you.
